It is highly recommended to use your Codex Scanner to seek and find Tumor Nodes as they can be hard to spot or find.

Tumor Nodes will always have two glowing orange trails near them at all times. Look for these trails to help spot a node.

Tumor Nodes can be damaged by weapons with AOE damage.

It is also recommended to stay with the same group of players for multiple runs to guarantee a higher score per run.

Make sure to bring something that can heal you or your team (Such as Team Heal Restores, the Rejuvenation aura, Oberon's Renewaland Reckoning, Nekros' Desecrate, and Trinity's Blessing) as there are a lot of dangers that can directly target your health or lead to your health being exposed.

• Alternatively, using mods such as Vitality, Antitoxin and Steel Fiber to help you stand better chance against toxic attacks.

Use Loki's Invisibility or Ash's Smoke Screen to stay invisible and focus on destroying the nodes and tumors while ignoring the Infested, allowing you to clear a level in relative safety.